Elslager, Edward F.; Jacob, Patricia; Werbel, Leslie M. published an article in 1972, the title of the article was Antimalarial drugs. 28. Folate antagonists. 6. Synthesis and antimalarial effects of fused 2,4-diaminothieno [2,3-d] pyrimidines.Category: nitriles-buliding-blocks And the article contains the following content:
2,4-Diamino-5,7 – dihydro – 6H – thiopyrano[4 ,3 :4,5]thieno[2,3-d]pyrimidine, 2,4-diamino-9H-indeno[1 ,2 :4,5]thieno[2,3-d]-pyrimidine, 2,4-diamino – 5H – indeno[2 ,1 :4,5]thieno[2,3 – d]-pyrimidine, 9,11-diamino-5,6-dihydronaphtho[1 ,2 :4,5]thieno-[2,3-d]pyrimidine, 7,9-diamino-5,6-dihydronaphtho[2 ,1 :4,5]-thieno[2,3-d]pyrimidine, 2,4-diamino – 7 – benzyl – 5,6,7,8 – tetrahydropyrido[4 ,3 :4,5]thieno[2,3-d]pyrimidine, and various 2,4-diamino – 5,6,7,8 – tetrahydro – [1]benzothieno[2,3 – d]pyrimidines were prepared by cyclization of the requisite fused 2-aminothiophene-3-carbonitriles with ClC(:NH)Nh2.HCl. Several compounds exhibited strong inhibitory effects against Streptococcus faecalis (MGH-2), Staphylococcus aureus (UC-76), Streptococcus faecalis (ATCC 8043), Lactobacillus casei (ATCC 7469), and Pediococcus cerevisiae (ATCC 8081) in vitro, and three compounds displayed slight antimalarial activity against Plasmodium berghei in mice and Plasmodium falciparum (Uganda I) in vitro. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks
The Article related to thienopyrimidine diamino fused, antimalarial fused diaminothienopyrimidine, antibacterial fused diaminothienopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts