Abd El-Latif, Nehad A. et al. published their research in Monatshefte fuer Chemie in 2007 |CAS: 75629-62-8

The Article related to nicotinic acid indolecarboxaldehyde thioxopyrimidine preparation analgesic anticonvulsant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C12H7N3

On June 30, 2007, Abd El-Latif, Nehad A.; Amr, Abd El-Galil E.; Ibrahiem, Alhusain A. published an article.Formula: C12H7N3 The title of the article was Synthesis, reactions, and pharmacological screening of heterocyclic derivatives using nicotinic acid as a natural synthon. And the article contained the following:

A series of substituted pyridine derivatives were prepared from 3-acetylpyridine, which was prepared from the corresponding nicotinic acid as a natural starting material. Reaction of 3-acetylpyridine with indole-3-carboxaldehyde afforded the corresponding 3-β-(3-indolyl)(acryloyl)pyridine, which was treated with hydroxylamine hydrochloride in pyridine or acetic acid in the presence of sodium acetate to afford 3-β-(3-indolyl)(acryloyl)pyridine oxime and oxazole derivatives The oxime was treated with Et isothiocyanate or toluene-3,5-diisocyanate in refluxing dioxane to give the corresponding Et thiosemicarbazide and 3,5-bis(semicarbazide) derivative 3-β-(3-Indolyl)(acryloyl)pyridine was condensed with malononitrile in refluxing ethanol in the presence of piperidine as a catalyst to give a cyano(amino)pyran derivative, while it was condensed with Et cyanoacetate or malononitrile in the presence of ammonium acetate to yield (cyano)pyridone and cyano(amino)pyridine derivatives Cyclization of (acryloyl)pyridine with o-phenylenediamine in refluxing butanol led to the formation of the corresponding benzodiazepine via the intermediate A. Finally, cycloaddition reaction of (acryloyl)pyridine with thiourea yielded thioxopyrimidine, which was treated with chloroacetic acid to yield thiazolopyrimidine. An arylmethylene derivative was prepared by reacting thiazolopyrimidine with indole-3-carboxaldehyde or by treating thioxopyrimidine with indole-3-carboxaldehyde and chloroacetic acid in one step. The pharmacol. screening showed that many of the compounds thus prepared have good analgesic and anticonvulsant activities comparable to valdecoxib [i.e, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide] and carbamazepine as reference drugs. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to nicotinic acid indolecarboxaldehyde thioxopyrimidine preparation analgesic anticonvulsant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts