Yuan, Chang; Tan, Hao; Jiang, Xue-Fei; Liu, Si; Jiang, Lu; Cao, Qi-Ying; Xu, Xing-Jie; Deng, Xiao-Yan; Pan, Guan-Nan; Chen, Jian-Yang; Cui, Hai-Lei published an article in 2019, the title of the article was Phosphine-Catalyzed [3+2] Cycloaddition and Vinylation of Indole-Derived 伪,伪-Dicyanoolefins with 纬-Substituted Allenoates.COA of Formula: C12H7N3 And the article contains the following content:
A phosphine-catalyzed [3+2] cycloaddition of 纬-substituted allenoates RCH=C=CHR1 (R = H, Ph, 4-chlorophenyl, (CH2)4CH3; R1 = C(O)OCH2C6H5, C(O)OMe, C(O)OEt) with 伪,伪-dicyanoolefins I (R2 = SO2C6H5, tosyl, CH2C6H5, etc.; R3 = H, 5-Br, 5-MeO, 6-Cl) has been established, affording indole-incorporated highly functionalized cyclopentenes II. In addition, the vinylated indole-derived 伪,伪-dicyanoolefins III (R4 = Ph, 4-chlorophenyl, phenethyl) have also been realized under the same reaction conditions by switching to indole-derived 伪,伪-dicyanoolefins without protective group at N-1 position I (R2 = H). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).COA of Formula: C12H7N3
The Article related to indole dicyanoolefin preparation regioselective diastereoselective enantioselective, dicyanoolefin allenoate cycloaddition reaction phosphine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C12H7N3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts