On December 3, 2020, Grosse, Sandrine Celine; Deratt, Lindsey Graham; Vandyck, Koen; Raboisson, Pierre Jean-Marie Bernard; Pieters, Serge Maria Aloyssius; Kesteleyn, Bart Rudolf Romanie; Verschueren, Wim Gaston; Berke, Jan Martin; LeComte, Morgan Charles R.; Martinez Lamenca, Carolina; Jonckers, Tim Hugo Maria; Deng, Gang; Jiang, Yimin; Xu, Yanping; Cheng, Zhangling; Hu, Lili; Kuduk, Scott D. published a patent.COA of Formula: C8H5BrFN The title of the patent was Fused heterocyclic derivatives as antiviral agents and their preparation. And the patent contained the following:
The application describes fused heterocycle derivatives of formula I, pharmaceutical compositions comprising these compounds, chem. processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection. Compounds of formula I wherein A is absent and CH2; X is CH2 and O; Y is NH and derivatives; W is CHR3 and CH:CH2; Z is CO and CS; R1 is (un)substituted 5- to 10-membered (mono/bi)cyclic ring optionally containing heteroatoms; R2 is H and (un)substituted C1-4 alkyl; R3 is H, F, OH, (un)substituted C1-4 alkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of Et 2-(2-aminoethyl)-5-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxylate bistrifluoroacetate. The invention compounds were evaluated for their antiviral activity. From the assay, it was determined that compound II exhibited an EC50 value 9.628渭M and a CC50 value of > 50渭M. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN
The Article related to heterocycle preparation antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C8H5BrFN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts