On October 9, 2002, Dombroski, Mark Anthony; Laird, Ellen Ruth; Letavic, Michael Anthony; McClure, Kim Francis published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of novel benzotriazoles as anti-inflammatory compounds. And the patent contained the following:
The title compounds [I; Het = (un)substituted pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = H, alkyl, Ph, etc.; s = 0-5] which are potent inhibitors of MAP kinases, preferably p38 kinase (no data given), and are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders, were prepared Thus, treating a solution of 3-isopropyl-3H-benzotriazole-5-carbaldehydein THF with concentrate NH4OH followed by addition of piperazine and isocyanide II afforded III. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile
The Article related to benzotriazole preparation map p38 kinase inhibitor antiinflammatory, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts