On April 25, 2002, Nakao, Kazunari; Okumura, Yoshiyuki; Matsumizu, Miyako; Uneo, Naomi; Hashizume, Yoshinobu; Kato, Tomoki; Kawai, Akiyoshi; Miyake, Yoriko; Nukui, Seiji; Shinjyo, Katsuhiro; Taniguchi, Kana published a patent.Recommanded Product: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of imidazoarenes as antiinflammatory and analgesic agents.. And the patent contained the following:
Title compounds [I; Y1-Y4 = N, CH, CL; R1 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (substituted) 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N, S, etc.; B = halo-substituted alkylene, cycloalklylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (substituted) monocyclic or bicyclic aryl optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.], were prepared as prostaglandin E2 receptor antagonists, preferably as EP4 receptor antagonists. Thus, to 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine (preparation given) in CH2Cl2 was added p-toluenesulfonyl isocyanate followed by stirring for 3 h to give 56% 2-ethyl-5,7-dimethyl-3-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-3H-imidazo[4,5-b]pyridine. Preferred I inhibited PGE2-induced thermal hyperalgesia in rats with ED50<60 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 3-Chloro-4-nitrobenzonitrile
The Article related to imidazoarene preparation antiinflammatory analgesic, prostaglandin receptor antagonist imidazoarene preparation, benzimidazole imidazopyridine preparation ep4 antagonist analgesic antiinflammatory and other aspects.Recommanded Product: 3-Chloro-4-nitrobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts