Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.
Zhou, Bei;He, Yu-Juan;Tao, Yun-Feng;Liu, Lan-Xiang;Hu, Min;Chang, Zu-Hui;Lei, Hong;Lin, Jun;Lin, Tong;Du, Guan-Ben research published 《 Electrocatalytic synthesis of α,α-gem-dihalide ketones from α-mono-halide ketones and unexpected dimer condensation》, the research content is summarized as follows. A novel, environmentally friendly electrocatalytic process was developed to prepare α,α-gem-dihalide (F, Cl, and Br) ketones from α-mono-halide ketones in an aqueous solution containing alkali halide salts. The gem-dihalides had the same or different halogens on the same carbon, depending on the reactant and inorganic halide salt used. An electron-withdrawing group, such as carbonyl, located at the α-site of mono-halogenated carbon, was essential to the reaction. The electrosyntheses were performed under ambient conditions without inert gas protection and displayed yields of about 80%. This method avoided the classical haloform elimination reaction. However, when the aqueous solution contained NaOH, two α-mono-halide ketone mols. had a special dimer condensation. The reaction mechanisms were explored by conducting GC-MS, EPR, and CV with DFT calculations These revealed that in situ generation of a halogen radical initiated electrocatalytic halogenation, while the dimer condensation involved a hydroxyl radical-mediated C1 fragment elimination.
Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts