Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: Methyl 2-cyanoacetate.
Zhang, Tianyu;Zhang, Xiaoming;Guan, Ruqun;Hao, Yajuan;Yang, Hengquan research published 《 Acid or alkali droplets confined in mesoporous hollow carbon nanospheres for improving water-oil biphasic reactions》, the research content is summarized as follows. A solid acid/alkali catalyst with large reaction interface was prepared by using mesoporous hollow carbon nanospheres as a matrix for water-oil biphasic reaction system, in which acids and alkalis droplets were confined within the nanocavities by an equal volume impregnation method. Various characterization techniques such as TEM, SEM, and N2 adsorption had proved that the obtained hollow carbon spheres possess uniform morphol., tunable size (280 nm-510 nm), high sp. surface area (797 m2/g-1305 m2/g) and large mesoporous diameter (6 nm-10 nm). After confining with acid/alkalis, the yielded catalyst showed much higher activity than those catalysts prepared from SBA-15 and Pickering emulsion catalytic system in the acid-catalyzed alc. addition reactions and alkali-catalyzed aldehyde condensation reactions (such as acid catalysis: TOF 689 vs 228, 32 h-1). In addition, the confined solid catalyst can also be used for continuous flow reactions, and the catalytic activity does not decrease obviously over 500 h, indicating that the prepared catalyst has high stability in water-oil biphasic systems.
Recommanded Product: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts