Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Product Details of C4H5NO2.
Zaydi, K. M. Al;Al-Johani, M. A.;Alqahtani, N. F.;Mousally, S. M.;Elnagdi, N. Hilmy research published 《 Reactions under Pressure: Synthesis of Functionally Substituted Arylhydrazonal Derivatives as Precursors of Novel Pyridazines and Nicotinates》, the research content is summarized as follows. Q-tube assisted multicomponent synthesis of novel arylhydrazonals I (R = Me; X = H, Me, NO2, Cl), pyridazines II (R = Ph, 4-chlorophenyl; X = H, Me, NO2; R1 = C(O), CHC(O)OMe) and nicotinates III (R = Ph, 2-thienyl, 4-chlorophenyl; X = H, Me; R2 = CN, C(O)Ph) has been explored. The target mols. II, III have been prepared via one pot reaction of arylhydrazonals I (R = Ph, 2-thienyl, 4-chlorophenyl; X = H, Me, NO2) with activated methylene nitriles in either ethanolic piperidine, di-Me acetylene dicarboxylate (DMAD), 1,4-diazobicyclo[2.2.2]octane (DABCO), or Ph3P under pressure. Such conditions make reaction time much shorter and yields higher as compared with those conducted under conventional conditions. The structures of products have been determined by X-ray crystallog. and spectroscopic methods.
Product Details of C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts