Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Electric Literature of 105-34-0.
Xu, Jimin;Xie, Xuping;Chen, Haiying;Zou, Jing;Xue, Yu;Ye, Na;Shi, Pei-Yong;Zhou, Jia research published 《 Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent Dengue virus inhibitors》, the research content is summarized as follows. The effective treatment for dengue virus infection continues to be a challenge. The authors herein reported the authors’ continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3-́ or 5-́site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the Ph ring, di-substitution on the Ph ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound Among these mols., compounds (JMX0376) with 4-chloro-3-fluorobenzyl and (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to -3 with nanomolar to low micromolar EC50 values.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Electric Literature of 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts