Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Computed Properties of 20099-89-2.
Williams, Matthew B.;Boyer, Alistair research published 《 Modular Synthesis of Highly Substituted 3-Azapyrroles by Rh(II) Catalyzed N-H Bond Insertion and Cyclodehydration》, the research content is summarized as follows. A modular synthesis of highly substituted 3-azapyrroles, e.g., I has been developed using a three-step sequence comprising: copper catalyzed alkyne-azide cycloaddition (CuAAC), N-H bond insertion and cyclodehydration. The compound 1-sulfonyl-1,2,3-triazoles (1-STs), e.g., 4-tolyl-1-tosyl-triazole can be accessed from common alkynes, e.g., 4-ethynyltoluene and sulfonyl azides, e.g., 4-toluenesulfonyl azide building blocks by CuAAC using copper(I) thiophene-2-carboxylate. Rhodium(II) acetate promoted 1-ST denitrogenation results in highly electrophilic rhodium azavinyl carbenes that, here, underwent insertion into the N-H bond of secondary α-aminoketones, e.g., 1-(4-tolyl)-2-(4-tolylamino)ethan-1-one to form 1,2-aminoalkenes, e.g., 1-[(2-oxo-2-(4-tolyl)ethyl)(4-tolyl)amino]-1-(4-tolyl)-2-(tosylamino)ethene. These products were cyclized and dehydrated using BF3OEt2 into highly substituted 3-azapyrroles, e.g., I. The three steps: CuAAC, N-H bond insertion and cyclodehydration could be telescoped into a one-pot process. The method proved to be highly efficient and tolerated a wide range of substituents.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Computed Properties of 20099-89-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts