Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Related Products of 3032-92-6.
Treat, Anny;Henri, Vianie;Liu, Junke;Shen, Joyce;Gil-Silva, Mauricio;Morales, Alejandro;Rade, Avaneesh;Tidgewell, Kevin Joseph;Kolber, Benedict;Shen, Young research published 《 Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice》, the research content is summarized as follows. Capsaicin, the compound in hot chili peppers responsible for their pungency and an agonist of the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), has long been known to promote the desensitization of nociceptors at high concentrations This has led to the utilization and implementation of topical capsaicin cream as an analgesic to treat acute and chronic pain. Critically, the application of capsaicin cream is limited due to capsaicin′s high pungency, which is experienced prior to analgesia. To combat this issue, novel capsaicin analogs were developed to provide analgesia with reduced pungency. Analogs reported in this paper add to and show some differences from previous structure-activity relationship (SAR) studies of capsaicin-like mols. against TRPV1, including the necessity of phenol in the aromatic “A-region”, the secondary amide in the “B-region”, and modifications in the hydrophobic “C-region”. This provided a new framework for de novo small-mol. design using capsaicin as the starting point. In this study, we describe the synthesis of capsaicin analogs, their in vitro activity in Ca2+ assays, and initial in vivo pungency and feasibility studies of capsaicin analogs YB-11 and YB-16 as analgesics. Our results demonstrate that male and female mice treated with YB capsaicin analogs showed diminished pain-associated behavior in the spontaneous formalin assay as well as reduced thermal sensitivity in the hotplate assay.
3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.
4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Related Products of 3032-92-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts