Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Name: 4-Ethynylbenzonitrile.
Sun, Yaru;Tang, Xiaochan;Li, Xiaobing;Kong, Xiuqi;Tian, Minggang;Wang, Yue;Dong, Baoli research published 《 PET-ESIPT-based fluorescent probes for revealing the fluctuation of peroxynitrite (ONOO–) in living cells, zebrafishes and brain tissues》, the research content is summarized as follows. Peroxynitrite (ONOO–) plays crucial roles in a variety of physiol. and pathol. processes in living systems, and therefore, real-time and in situ imaging of ONOO– is of great significance to in-depth study its biol. roles. Herein, we have developed PET-ESIPT-based fluorescent probes (BCN and BCN-A) for the detection of ONOO– in living cells, zebrafishes and brain tissues. BCN was a highly sensitive ONOO– probe in which the fluorescence property of the fluorophore was simultaneously controlled by PET and ESIPT mechanisms, and transformed to BCN-A via acetylation. Especially, BCN showed large Stokes shift in response to ONOO–, and displayed high selectivity to ONOO–. BCN-A employed the acetate group to switch off ESIPT process of the fluorophore and improve the membrane permeability. In living cells, BCN-A released an ONOO–-responsive probe (BCN) by the hydrolysis of esterase, and then detected ONOO–. Biol. imaging demonstrated that although both metformin and rotenone are mitochondrial complex I inhibitors, metformin can increase the generation of ONOO– while rotenone had no significant influence on the generation of ONOO– in living cells and zebrafishes. Moreover, the amygdala and perirhinal/entorhinal cortex in the brain of depressive mouse both showed increasing fluorescence intensity relative to those of normal mouse, which suggested that the LPS-induced depressive disorder could result in the generation of ONOO– in the two brain areas of mouse. We expect that the probes (BCN and BCN-A) could extensively serve as the powerful mol. tools to investigate the biol. roles of ONOO– for the in-depth study of drug mechanism and depressive disorder.
Name: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.
4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts