Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Synthetic Route of 20099-89-2.
Song, Dan;Huang, Changfeng;Liang, Peishi;Zhu, Baofu;Liu, Xiang;Cao, Hua research published 《 Lewis acid-catalyzed regioselective C-H carboxamidation of indolizines with dioxazolones via an acyl nitrene type rearrangement》, the research content is summarized as follows. An efficient, direct, and novel Lewis acid-catalyzed regioselective C-H carboxamidation of indolizines with dioxazolones via an acyl nitrene type rearrangement under metal-free conditions was documented. A diverse array of indolizine-3-carboxamides I [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, 8-Me, 6-Et, etc.; R2 = Ph, 4-MeC6H4, 2-FC6H4, etc.] were achieved in moderate to good yields with wide substrate scope. In these transformations, isocyanatobenzene was formed by the ring opening of dioxazolones and a subsequent Curtius-type rearrangement, which could be harnessed in C-H carboxamidation of N-heterocycles. The present protocol is satisfactorily complementary to nitrene transfer chem. and C-H functionalization of N-heterocycles. Furthermore, photophys. experiments revealed that a few compounds exhibited high fluorescence absorption and emission intensity.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts