Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 20099-89-2.
Shelke, Sushil V.;Dhumal, Sambhaji T.;Karale, Akshay Y.;Deshmukh, Tejshri R.;Patil, Meghshyam K. research published 《 A facile synthesis of quinoxalines by using SO42-/ZrO2-TiO2 as an efficient and recyclable heterogeneous catalyst》, the research content is summarized as follows. Quinoxaline derivatives have been synthesized in good to excellent yields by the cyclocondensation reaction of o-pheneylenediamine with substituted phenacyl bromides/benzil in the presence of SO42-/ZrO2-TiO2 as an efficient and heterogeneous catalyst. The catalyst can be recovered up to five catalytic cycles without significant loss in catalytic activity. The reported SO42-/ZrO2-TiO2 catalyst has been thoroughly characterized by using IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), and powder X-ray diffraction (XRD). Here, we have used ethanol as a green solvent in this cyclocondensation. This new method has several advantages, such as excellent yields, short reaction time, nontoxic, and easily recoverable cyclocondensation catalyst.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts