Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Methyl 2-cyanoacetate.
Shaw, Ranjay;Pratap, Ramendra research published 《 A Green and Base-Free Arylation of Thiomethylated 2-pyranones and Ketene Dithioacetals via Liebeskind-Srogl Coupling in Water》, the research content is summarized as follows. A green and base-free desulfitative coupling of different thioethers I (X = CN, COOMe; Ar1 = 4-methoxyphenyl, 4-fluorophenyl, thiophen-2-yl;) with aryl boronic acids Ar2B(OH)2 (Ar2 = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) to botain II in water was described. Various thiomethylated 2H-pyran-2-ones I (X = CN, COOMe), 2-oxobenzo[h]chromones II and α-aroyl ketene-dithioacetals R2CH(O)CH=C(SCH3)2 (R2 = Ph, naphthalen-2-yl, thiophen-2-yl, etc.) were used as substrate to obtained arylated product I, II in very good to excellent yield. Further utility of reaction was carried out by a one-pot arylation followed by amination of α-aroyl ketene dithioacetals for the synthesis of 1-(4-bromophenyl)-3-morpholino-3-phenylprop-2-en-1-one and diarylazoles III (R3 = Ph, 4-methoxyphenyl, furan-2-yl, etc.; R4 = Ph, thiophen-3-yl, etc.; X = NH, O). The structure of isolated product 2-Oxo-4-phenyl-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile and (Z)-1-(4-Bromophenyl)-3-(methylthio)-3-phenylprop-2-en-1-one was ascertained by spectroscopic and single crystal X-ray diffraction analyses.
Recommanded Product: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts