Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Electric Literature of 3032-92-6.
Scapin, Elisandra;Zimmer, Georgia C.;Vieira, Jean C. B.;Rodrigues, Catarina A. B.;Afonso, Carlos A. M.;Zanatta, Nilo;Bonacorso, Helio G.;Frizzo, Clarissa P.;Martins, Marcos A. P. research published 《 Reactivity of trifluoromethyl-tetrazolo[1,5-a]pyrimidines in click chemistry and hydrogenation》, the research content is summarized as follows. The synthetic potential of tetrazolo[1,5-a]pyrimidines to obtain new pyrimidine derivatives via click chem. and hydrogenation was reported. Click chem. reactions of trifluoromethyl-tetrazolo[1,5-a]pyrimidines with terminal acetylenes produced unprecedented trifluoromethylated triazolylpyrimidines at excellent yields (84-98%), and one of them was active against all tested microorganisms, with moderate min. inhibitory concentration values (62.5-15.62μg/mL). Hydrogenation was performed using Pd/C-H2 in MeOH under conventional, photochem., and pressure (5 bar) conditions. Hydrogenation was an excellent method for obtaining 2-amino-6-aryl-4-trifluoromethylpyrimidines and/or 2-amino-6-aryl-4-trifluoromethyltetrahydropyrimidines with a preference for 2-aminopyrimidine formation. Photochem. hydrogenation was the only pathway for reducing aryl-brominated substrates without dehalogenation. The reduction of trifluoromethyl-substituted tetrazolo[1,5-a]pyrimidines furnished 2-amino-6-aryl-4-trifluoromethylpyrimidines instead of the corresponding tetrahydropyrimidines. However, the hydrogenation of non-trifluoromethylated tetrazolo[1,5-a]pyrimidines showed a preference for tetrahydropyrimidine formation.
Electric Literature of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.
4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts