Zhu, Xing-Li; He, Wu-Jun; Yu, Liang-Liang; Cai, Chang-Wu; Zuo, Zong-Le; Qin, Da-Bin; Liu, Quan-Zhong; Jing, Lin-Hai published an article in 2012, the title of the article was Organocatalytic asymmetric vinylogous Michael addition of dicyanoolefins to imine intermediates generated in situ from arenesulfonylalkylindoles.Synthetic Route of 2510-01-2 And the article contains the following content:
An organocatalytic asym. vinylogous Michael addition of dicyanoolefins to vinylogous imine intermediates generated in situ from arenesulfonylalkylindoles has been developed. This protocol provides an easy and convenient approach to C-3 alkyl-substituted indole derivatives with high yields (up to 93%), diastereomeric ratios (up to 99:1 dr) and enantioselectivities (up to 99% ee). The resulting adducts can be also readily converted to pyrazolo derivatives or α-alkylation products of ketones without any decrease of the diastereoselectivities and enantioselectivities. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2
The Article related to arenesulfonylalkylindole imine organocatalytic asym vinylogous michael addition dicyanoolefin, alkyl indole derivative enantioselective diastereoselective synthesis alkylation ketone pyrazole, michael adduct crystal structure and other aspects.Synthetic Route of 2510-01-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts