On January 20, 2011, Papeo, Gianluca Mariano Enrico; Anatolievna Busel, Alina; Khvat, Alexander; Krasavin, Mikhail Yurievitch; Forte, Barbara; Zuccotto, Fabio published a patent.Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate The title of the patent was Preparation of 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors. And the patent contained the following:
The title compounds I [R = alkyl, alkenyl, alkynyl (each group substituted with one or more substituents selected from either NR3R4, Oalkyl, CO2alkyl and CONRaRb; wherein Ra, Rb = alkenyl, alkynyl, etc.; or NRaRb = (un)substituted heterocyclyl); R1 = H, halo, CN, NO2, etc.; R3, R4 = H, alkenyl, alkynyl, etc.; or NR3R4 = (un)substituted heterocyclyl] which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2, and therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation, were prepared and claimed. Thus, reacting 3-oxo-2-(piperidin-4-yl)-2,3-dihydro-1H-isoindole-4-carboxylic acid amide with 4,4-difluorocyclohexanone afforded the amide II. Exemplified compounds I were tested for their activity as PARP inhibitors (data given). The present invention also provides methods for preparing compounds I, pharmaceutical compositions comprising these compounds, and methods of treating, diseases utilizing pharmaceutical compositions comprising these compounds The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate
The Article related to oxoisoindolecarboxamide preparation parp inhibitor combination chemotherapy antitumor cardiovascular, central nervous system injury treatmentoxoisoindolecarboxamide preparation parp inhibitor, antiinflammatory isoindolecarboxamide oxo preparation parp inhibitor and other aspects.Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts