On September 12, 1989, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of alkanesulfonanilide derivatives as analgesics and inflammation inhibitors. And the patent contained the following:
Title compounds I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy; R3 = alkyl; R4 = acyl, cyano, HO2C, hydroxyalkyl, HS, alkylthio, alkylsulfinyl, alkylsulfonyl, Q, R7N:CR6, alkanoylalkenyl, (un)substituted 5-membered unsat. heterocyclyl, PhS; R6 = H, H2N, alkyl; R7 = OH, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, H2NCONH, H2NCSNH; R5 = H, halo, alkyl, alkanoyl] and pharmaceutically acceptable salts thereof were prepared I are also useful for treating pyretic diseases, rheumatism, and arthritis. 4′-Amino-3′-(2,4-difluorophenoxy)acetophenone (preparation given) and MeSO2Cl in pyridine were stirred overnight at room temperature to give I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-Ac; R8 = 4-F). Similarly prepared was I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-cyano; R8 = 4-F) (II). The analgesic activity was demonstrated with II showing an oral ED50 at 2.4 mg/kg in the HOAc-induced writhing test in mice (cf. 1.6 mg/kg for indomethacin). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8
The Article related to alkanesulfonanilide preparation analgesic antiinflammatory, sulfonanilide alkane preparation analgesic antiinflammatory, antirheumatic alkanesulfonanilide preparation, antipyretic alkanesulfonanilide preparation, antiarthritic alkanesulfonanilide preparation and other aspects.HPLC of Formula: 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts