On February 21, 2007, Liu, Tian-Yu; Cui, Hai-Lei; Long, Jun; Li, Bang-Jing; Wu, Yong; Ding, Li-Sheng; Chen, Ying-Chun published an article.Application of 2510-01-2 The title of the article was Organocatalytic and Highly Stereoselective Direct Vinylogous Mannich Reaction. And the article contained the following:
The first direct asym. vinylogous Mannich (AVM) reaction of α,α-dicyanoolefins and N-Boc aldimines was described promoted by a simple chiral bifunctional thiourea-tertiary amine organocatalyst. The reaction was highly efficient (S/C up to 1000) and regio-, stereoselective (generally >99% de, >96% ee) at room temperature for a broad array of substrates. Enantiomerically pure δ-amino acid and subsequential δ-lactam could be smoothly prepared from the adduct. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2
The Article related to dicyanoolefin aldimine chiral thiourea tertiary amine asym vinylogous mannich, dicyanovinyl amine stereoselective preparation reduction hydrolysis, amino acid stereoselective preparation amidation, lactam stereoselective preparation, asym vinylogous mannich catalyst chiral thiourea tertiary amine and other aspects.Application of 2510-01-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts