Zhou, Quan-Quan; Zou, You-Quan; Kar, Sayan; Diskin-Posner, Yael; Ben-David, Yehoshoa; Milstein, David published an article in 2021. The article was titled 《Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration and α-Deuterated Amide Formation via Metal Ligand Cooperation》, and you may find the article in ACS Catalysis.Related Products of 31938-07-5 The information in the text is summarized as follows:
A simple and efficient system for the hydration and α-deuteration of nitriles to form amides RC(O)NH2 [R = Me, Bn, 4-FC6H4, etc.] and α-deuterated nitriles R1CD2CN [R1 = PhCH2CH2, 3-MeC6H4, 3-pyridyl, etc.] catalyzed by a single pincer complex of the earth-abundant manganese capable of metal-ligand cooperation is reported. The deuteration reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D2O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D2O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal-ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Related Products of 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts