In 2022,Zhao, Rongrong; Wen, Simiaomiao; Fu, Hao; Liu, Mengna; Liu, Qixing; Zhou, Haifeng published an article in Green Chemistry. The title of the article was 《Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen》.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:
A simple, efficient and clean approach for the synthesis of diverse dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones and analogs through intramol. acceptorless dehydrogenative coupling has been achieved. The combination of bis(2-methoxyethyl)ether and mol. oxygen was identified as a highly efficient system for this oxidative dehydrogenative coupling sequential transformation without an external initiator, catalyst and additive. The applicability and practicability were demonstrated by a scope of twenty-nine examples and a gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts