In 2022,Zhang, Xiuqi; Zhang, Fukuan; Li, Xiaolan; Lu, Ming-Zhu; Meng, Xin; Huang, Lei; Luo, Haiqing published an article in Organic Letters. The title of the article was 《Direct Synthesis of Biphenyl-2-carbonitriles by Rh(III)-Catalyzed C-H Hiyama Cross-Coupling in Water》.COA of Formula: C7H4FN The author mentioned the following in the article:
This method represents an efficient rhodium(III)-catalyzed O-C-H arylation of readily available benzimidate derivatives 2-R-3-R1-4-R2C6H2C(=NH)OR3 (R = H, F, MeO; R1 = H, Me, Br, MeO, F; R2 = H, CF3, I, etc.; R3 = Et, t-Bu, i-Pr, Me) with diverse arylsilanes ArSi(OEt)3 (Ar = 4-methoxyphenyl, 1-naphthyl, thiophen-2-yl, benzodioxol-5-yl, etc.) in water as a sustainable solvent, enabling the straightforward synthesis of potentially useful biphenyl-2-carbonitrile derivatives I. This silicon-based protocol employs benzimidates as both an efficacious directing group and the source of a nitrile group. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1COA of Formula: C7H4FN)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.COA of Formula: C7H4FN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts