Zhang, Jun-Qi; Liu, Jiayue; Hu, Dandan; Song, Jinyu; Zhu, Guorong; Ren, Hongjun published an article in 2022. The article was titled 《Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes》, and you may find the article in Organic Letters.Category: nitriles-buliding-blocks The information in the text is summarized as follows:
A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitriles derivatives RCH(R1)CN [R = Ph, 4-ClC6H4, 4-NO2C6H4, etc.; R1 = H, Me, 2-ClC6H4, etc.] was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope and broad functional group tolerance. Significantly, in this reaction, aqueous ammonia offers “”N”” source for the “”CN”” reagent and entirely avoided the use of toxic cyanating regents or metal catalysis. Hence, provided a green and alternative method for the synthesis of arylacetonitriles. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts