Yadav, Upasana’s team published research in ChemistrySelect in 2020 | CAS: 17201-43-3

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Application of 17201-43-3

《Design and Synthesis of 5-Morpholino-Thiophene-Indole/Oxindole Hybrids as Cytotoxic Agents》 was written by Yadav, Upasana; Sakla, Akash P.; Tokala, Ramya; Nyalam, Sai Teja; Khurana, Amit; Digwal, Chander Singh; Talla, Venu; Godugu, Chandraiah; Shankaraiah, Nagula; Kamal, Ahmed. Application of 17201-43-3 And the article was included in ChemistrySelect in 2020. The article conveys some information:

A series of new 5-morpholino-thiophene-indole/oxindole hybrids (Z)-I (R1 = PhCH2, 4-MeOC6H4CH2, 4-NCC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 4-ClC6H4CH2; R2 = 4-MeOC6H4, 4-MeC6H4, 4-ClC6H4) and (Z)-II (R3 = H, Cl) has been designed and synthesized using mol. hybridization approach. The synthesized compounds I and II were evaluated for their in vitro cytotoxic potential against selected human cancer cell lines such as triple neg. breast (MDA-MB-231), liver (SK-Hep-1), breast (MCF-7), colon (HCT-116) mouse melanoma (B16F10) and compared with normal human lung epithelial cell line (BEAS-2B). Among I and II, I (R1 = PhCH2; R2 = 4-MeC6H4) (III) showed significant cytotoxicity in HCT-116 cancer cells with an IC50 value of 8.98 ± 0.6μM. Cell cycle anal. revealed that selected compounds arrested the cell cycle in sub-G1 phase. Moreover, JC-1, acridine orange, DAPI nucleic acid, and DCFDA staining studies suggest that III inhibited cellular proliferation through induction of apoptosis. Further, mol. docking and relative viscosity studies of III indicated that III bound in the minor groove of calf thymus DNA. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Application of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts