《Continuous flow Suzuki-Miyaura couplings in water under micellar conditions in a CSTR cascade catalyzed by Fe/ppm Pd nanoparticles》 was published in Green Chemistry in 2020. These research results belong to Wood, Alex B.; Nandiwale, Kakasaheb Y.; Mo, Yiming; Jin, Bo; Pomberger, Alexander; Schultz, Victor L.; Gallou, Fabrice; Jensen, Klavs F.; Lipshutz, Bruce H.. Synthetic Route of C7H4BrN The article mentions the following:
The first demonstration of aqueous surfactant-enabled Suzuki-Miyaura couplings run under flow conditions was described. In addition, use of an even more challenging heterogeneous nanoparticle catalyst, containing only 800 ppm of Pd (i.e., 0.08 mol%) in the form of Fe/ppm Pd nanoparticles, was sufficient using a continuous stirred-tank reactor (CSTR). In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Synthetic Route of C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts