Wang, Yinan; Chen, Hui; Sheng, Ruilong; Fu, Zhe; Fan, Junting; Wu, Wenhui; Tu, Qidong; Guo, Ruihua published an article in 2021. The article was titled 《Synthesis and bioactivities of marine pyran-isoindolone derivatives as potential antithrombotic agents》, and you may find the article in Marine Drugs.Name: 4-Cyanobenzyl bromide The information in the text is summarized as follows:
2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-teraahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran-isoindolone derivative isolated from a rare marine microorganism Stachybotrys longispora FG216, which showed moderate antithrombotic (fibrinolytic) activity. To further enhance its antithrombotic effect, a series of new FGFC1 derivatives I (R = CH3, Et, Pr, etc.) were synthesized via chem. modification at C-2 and C-2″” phenol groups moieties and C-1″” carboxyl group. Their fibrinolytic activities in vitro were evaluated. Among the derivatives, I (R = CH3, Et, Pr, 4-CNC6H4CH2 and 4-BrC6H4CH2) showed significant fibrinolytic activities with EC50 of 59.7, 87.1, 66.6, 82.8, and 42.3μM, resp., via enhancement of urokinase activity. Notably, derivative I (R = 4-BrC6H4CH2) presented the most remarkable fibrinolytic activity (2.72-fold than that of FGFC1). Furthermore, the cytotoxicity of derivative I (R = 4-BrC6H4CH2) was tested as well as expression of Fas/Apo-1 and IL-1 on HeLa cells. The results showed that, compared to FGFC1, derivative I (R = 4-BrC6H4CH2) possessed moderate cytotoxicity and apoptotic effect on HeLa cells (statistical significance p > 0.1), making (R = 4-BrC6H4CH2) a potential antithrombotic agent towards clin. application. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)
4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Name: 4-Cyanobenzyl bromide
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts