In 2022,Wang, Qiao-Lin; Sun, Zhaozhao; Huang, Huawen; Mao, Guojiang; Deng, Guo-Jun published an article in Green Chemistry. The title of the article was 《Stoichiometric couplings of methylarenes through visible-light-induced bromo radical formation from aryl halides》.Application In Synthesis of 2-Bromobenzonitrile The author mentioned the following in the article:
A visible-light/nickel dual catalyzed stoichiometric coupling of methylarenes via bromine radical-enhanced HAT was developed. Aryl bromides serve as both cross-coupling partners and bromine radical precursors. Mechanistic studies revealed that the bromine radical acts as a highly efficient HAT reagent to abstract the benzylic C(sp3)-H bond to deliver a benzylic radical and subsequently engages in Ni-catalyzed arylation couplings. The synthetic utility of this approach was further proved by its application in the late-stage arylation or benzylation of several drug-like and complex mols. in a stoichiometric manner. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Application In Synthesis of 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts