In 2022,Suzuka, Toshimasa; Niimi, Ryoko; Uozumi, Yasuhiro published an article in Synlett. The title of the article was 《Cyanide-Free Cyanation of Aryl Iodides with Nitromethane by Using an Amphiphilic Polymer-Supported Palladium Catalyst》.Synthetic Route of C7H4BrN The author mentioned the following in the article:
A cyanide-free aromatic cyanation was developed that used nitromethane as a cyanide source in water with an amphiphilic polystyrene-poly(ethylene glycol) resin-supported palladium catalyst and an alkyl halide (1-iodobutane). The cyanation proceeded through the palladium-catalyzed cross-coupling of an aryl halide with nitromethane, followed by transformation of the resultant (nitromethyl)arene intermediate into a nitrile by 1-iodobutane. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Synthetic Route of C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts