Pan, Ming; Shao, Ying-Bo; Zhao, Qun; Li, Xin published an article in 2022. The article was titled 《Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations》, and you may find the article in Organic Letters.Reference of 4-Cyanobenzyl bromide The information in the text is summarized as follows:
A wide range of N-N axially chiral quinazolinone derivatives I (R1 = Ph, prop-1-en-2-yl, 3-chlorphenyl, etc.; R2 = Ph, 1-naphthyl, prop-1-ynyl, etc.; R3 = Ph, t-Bu, 3-bromophenyl, etc.; R4 = H, 7-Me, 6-I, 5-Cl, etc.) were prepared by phase-transfer catalysis in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. D. functional theory calculations provide insight into the mechanism. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)
4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Reference of 4-Cyanobenzyl bromide
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts