《Photoredox-Catalyzed Site-Selective Generation of Carbanions from C(sp3)-H Bonds in Amines》 was written by Murugesan, Kathiravan; Donabauer, Karsten; Narobe, Rok; Derdau, Volker; Bauer, Armin; Koenig, Burkhard. Formula: C43H30F2N4 And the article was included in ACS Catalysis on April 1 ,2022. The article conveys some information:
Herein, activation of a C(sp3)-H bond in the α-position to an amine via a carbanion intermediate was described. In the presence of several α-amine sites, only one specific position was selectively activated. Applying this protocol, the proposed carbanion intermediate was effectively trapped with different electrophiles such as deuterium (D+), tritium (T+), or carbonyl compounds compiling over 50 examples. Further, this methodol. was used to install deuterium or tritium in different drug-derivatives (>10 drugs) at a selected position in a late-stage functionalization. In addition, the protocol was suitable for a gram-scale synthesis, and a detailed mechanistic investigation was carried out to support our hypothesis. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Formula: C43H30F2N4)
2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Formula: C43H30F2N4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts