Jadhav, Chetan; Nipate, Amol; Chate, Asha; Gill, Charansingh published their research in ACS Omega in 2021. The article was titled 《Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids》.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The article contains the following contents:
An operationally simple, one-pot multicomponent reaction was developed for the assembly of pyrido[2,3-d]pyrimidine and pyrazolo[3,4-b]pyridine derivatives I [R1 = 4-ClC6H5, 2-OHC6H5, 4-BrC6H5; R2 = C6H5, 4-Cl-C6H5, etc], II [R1 = 4-ClC6H5, 4-MeC6H5 , 4-BrC6H5; R2 = C6H5, 4-ClC6H5; R3 = R4 = H, Me, etc], III [R1 = 4-ClC6H5, 4-MeC6H5; R2 = C6H5; R5 = NH2, etc] in excellent yields (92-94%) with high purity. The reactions were easy to perform simply by mixing of electron-rich amino heterocycles (including aminouracils and aminopyrazoles), aldehyde, and acyl acetonitrile in the presence of [Et3NH][HSO4] under solvent-free conditions. The remarkable feature of the present approach was that the ionic liquid possesses dual solvent-catalytic engineering capability. Results of this study revealed that 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60°C is the best reaction parameter for the construction of fused pyridine and pyrimidine derivatives I, II and III in excellent yields. The present methodol. showed good results under gram-scale conditions, thereby indicating its applicability in industrial as well as academic settings in the near future. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts