In 2022,Jacob, Raquel G.; Hartwig, Daniela; Nascimento, Jose Edmilson R.; Abib, Paola B.; Ebersol, Camila P.; Nunes, Pamela P. P.; Birmann, Paloma T.; Casaril, Angela M.; Savegnago, Lucielli; Schumacher, Ricardo F. published an article in Tetrahedron Letters. The title of the article was 《Sequential one-pot synthesis and antioxidant evaluation of 5-amino-4-(arylselanyl)-1H-pyrazoles》.Name: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:
A simple and efficient method for the sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy under mild conditions was described. The starting materials were easily available benzoylacetonitriles, substituted hydrazines and diaryl diselenides. A range of substituted 5-amino-4-(arylselanyl)-1H-pyrazoles was obtained in moderate to good yields (49% to 90%). Moreover, the antioxidant effect of the 5-amino-4-(arylselanyl)-1H-pyrazoles were reported in several in-vitro trials, which is extremely important, because oxidative stress is a crucial role in the development of various human diseases. This data revealed that all compounds demonstrated promising effects in scavenging the synthetic radical ABTS+, presented reducing power in ferric ion reducing antioxidant power (FRAP) assay, and ability to inhibit linoleic acid peroxidation Thus, these compounds can be interesting synthetic mols. in the protection from oxidative diseases. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts