The author of 《Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids》 were Han, Chong; Kelly, Sean M.; Cravillion, Theresa; Savage, Scott J.; Nguyen, Tina; Gosselin, Francis. And the article was published in Tetrahedron in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:
An efficient synthesis of PI3K inhibitor GDC-0077, featuring two consecutive Cu-catalyzed C-N coupling reactions, is reported. The described synthetic route involves a chemoselective Ullmann-type coupling of a chiral difluoromethyl-substituted oxazolidinone, a Cu-catalyzed N-arylation of L-alanine with high stereochem. integrity, and a high-yielding final amide bond formation step to produce GDC-0077 in >99.5 area % HPLC purity. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Category: nitriles-buliding-blocks It is used in the synthesis of heterocycles and liquid crystals.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts