Hammann, Jeffrey M.’s team published research in Organic Letters in 2017 | CAS: 105942-08-3

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

In 2017,Hammann, Jeffrey M.; Thomas, Lucie; Chen, Yi-Hung; Haas, Diana; Knochel, Paul published 《Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides》.Organic Letters published the findings.Product Details of 105942-08-3 The information in the text is summarized as follows:

In the presence of CoCl2·2LiCl and TMEDA, selected terminal alkynylzinc pivalates underwent coupling with electron-deficient aryl and heteroaryl chlorides, bromides, and iodides and two alkenyl bromides to yield aryl alkynes and enynes chemoselectively; coupling of a silylethynylzinc pivalate with an (E)-alkenyl bromide and a (Z)-bromoacrylate yielded the corresponding (E)-enyne and (Z)-enynoate in 99:1 dr. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts