Gladkov, Anton A.; Chernov, Grigory N.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Dilman, Alexander D. published their research in Organic Letters on December 17 ,2021. The article was titled 《Photoredox Activation of Organozinc Reagents: Barbier-Type Reaction of Alkyl Halides with α-(Trifluoromethyl)styrenes》.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The article contains the following contents:
Organozinc reagents were activated under blue light irradiation using an organic photocatalyst to generate alkyl radicals. The radicals were trapped by α-(trifluoromethyl)styrenes leading to gem-difluorinated products after elimination of fluoride. The reaction was conveniently performed under Barbier conditions starting from organic iodides and bromides and elemental zinc. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)
2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts