In 2019,Current Organic Synthesis included an article by Gao, Hui; Liu, Bei; Zhu, Ping; Zhang, Li-Jun; Wan, Chun-Ping; Rao, Gao-Xiong; Mao, Ze-Wei. Electric Literature of C8H6BrN. The article was titled 《Synthesis and Biological Evaluation of New Piperazine Substituted 3, 5-Diarylisoxazolines》. The information in the text is summarized as follows:
A series of new piperazine substituted 3,5-diphenylisoxazoline derivatives I [R = H, H3CCO, 4-O2NC6H4, etc.] were designed and synthesized and in-vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and anticancer effect against a panel of human tumor cell lines (Hela, A549 and SGC7901) by MTT assay were evaluated. Structure-activity relationship of the synthesized compounds I was conducted and concluded that the substituents of the NH group of piperazine ring had an obvious influence on biol. activities. Especially, compounds I [R = H, ClCH2CO, ClCH2CH2CO, 4-F3CC6H4CO, 3,5-ClC6H3CO, C6H5CHCHCO, 4-BrC6H4COCH2] showed good inhibitory effect on the generation of NO compared to dexamethasone. Furthermore, derivatives I [R = H, H3CCO, ClCH2CO, ClCH2CH2CO, H3COCOCH2CO, C6H5CHCHCO, 4-ClC6H4COCH2] were found to be potential selectively anticancer activity on human tumor cell lines, which displayed better cytotoxic activity to pos. control 5-FU. Piperazine substituted 3, 5-diarylisoxazoline derivatives could be considered as new antiinflammatory and anticancer agents. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN) was used in this study.
4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Electric Literature of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts