Egami, Hiromichi; Hotta, Ryo; Otsubo, Minami; Rouno, Taiki; Niwa, Tomoki; Yamashita, Kenji; Hamashima, Yoshitaka published an article in Organic Letters. The title of the article was 《Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst》.COA of Formula: C10H7BrN2 The author mentioned the following in the article:
Asym. dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeded under mild reaction conditions to provide fluoropyrroloindoline derivatives I [R1 = H, 4-Me, 5-Cl, etc.; R2 = H, Me, Bn, etc.; R3 = SO2Me, 4-MeC6H4SO2, C6H5SO2] in a highly enantioselective manner. Various substitution patterns on the indole ring were well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water was essential and its possible role was discussed. In the part of experimental materials, we found many familiar compounds, such as 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2COA of Formula: C10H7BrN2)
2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.COA of Formula: C10H7BrN2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts