In 2019,Chemical Science included an article by Donald, James R.; Berrell, Sophie L.. Synthetic Route of C8H6BrN. The article was titled 《Radical cyanomethylation via vinyl azide cascade-fragmentation》. The information in the text is summarized as follows:
A novel methodol. for radical cyanomethylation was described. The process was initiated by radical addition to the vinyl azide reagent 3-azido-2-methylbut-3-en-2-ol which triggered a cascade-fragmentation mechanism driven by the loss of dinitrogen and the stabilized 2-hydroxypropyl radical, ultimately effecting cyanomethylation. Cyanomethyl group was efficiently introduced into a range of substrates via trapping of α-carbonyl, heterobenzylic, alkyl, sulfonyl and aryl radicals, generated from a variety of functional groups under both photoredox catalysis and non-catalytic conditions. The value of this approach was exemplified by the late-stage cyanomethylation of pharmaceuticals. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Synthetic Route of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts