In 2019,ChemistrySelect included an article by Chen, Jing; Ding, Yuxin; Gao, Yejun; Zhou, Dongheng; Hider, Robert; Ma, Yongmin Dr. Application of 614-16-4. The article was titled 《Selectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF》. The information in the text is summarized as follows:
An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application of 614-16-4)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application of 614-16-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts