Cardenas, Jorge; Gavino, Ruben; Garcia-Rios, Erendira; Rios-Ruiz, Lucero; Puello-Cruz, Ana C.; Morales-Serna, Francisco Neptali; Gomez, Samuel; Lopez-Torres, Adolfo; Morales-Serna, Jose Antonio published their research in RSC Advances in 2021. The article was titled 《The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(II) complex and toxicity of the ligand precursor for the marine benthic copepod Amphiascoides atopus》.Synthetic Route of C7H4BrN The article contains the following contents:
The palladium-catalyzed reaction of aryl halides and allylic alcs. was an attractive method for obtaining α,β-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(II) complex formed in situ was found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcs., with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(II) complex for the harpacticoid copepod Amphiascoides atopus allowed to contrast the efficiency of the catalytic system with the potential impact of the principal waste chem. in global aquatic ecosystems, which has not been previously addressed. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Synthetic Route of C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts