In 2022,Alizadeh, Abdolali; Rostampoor, Azar published an article in ChemistrySelect. The title of the article was 《Efficient One Pot and Chemoselective Synthesis of Polysubstituted Dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones via a Four-Component Reaction》.Safety of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:
In this research, a simple and chemoselective synthesis of highly fluorescent polysubstituted dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones containing one chiral stereocenter was presented by a sequential four-component reaction of 4-chloro-3-formylcoumarin, 1-phenyl-2-(1,1,1-triphenyl-λ5-phosphanylidene)ethan-1-ones (Wittig reagent), benzoylacetonitriles and hydrazine hydrate as readily available starting materials, which includes base-mediated 1,4-addition/aza-Michael addition/formation of two C-N bonds. The desired products were obtained with short reaction times, easy purification (products can be purified by washing with EtOH), and medium to high yields (up to 92%) under relatively mild reaction conditions. Mol. structures were determined by IR spectrophotometry, mass spectrometry, NMR spectroscopy, and single-crystal X-ray anal. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts