In 2022,Akunuri, Ravikumar; Vadakattu, Manasa; Kaul, Grace; Akhir, Abdul; Saxena, Deepanshi; Ahmad, Mohammad Naiyaz; Bujji, Sushmitha; Joshi, Swanand Vinayak; Dasgupta, Arunava; Yaddanapudi, Venkata Madhavi; Chopra, Sidharth; Nanduri, Srinivas published an article in ChemistrySelect. The title of the article was 《Synthesis and Antibacterial Evaluation of 3,4-Dihydro-1H-benzo[b]azepine-2,5-dione Derivatives》.COA of Formula: C8H6BrN The author mentioned the following in the article:
Fused-azepinones are interesting heterocyclic scaffolds present in various natural products and synthetic derivatives with potent kinase inhibition, anti-cancer, anti-inflammatory, anti-HIV, neuroprotective, anti-fouling and other biol. activities. These fused-azepinones are also known for their antimicrobial activity against the Plasmodium falciparum, Leishmania, Escherichia coli, and Streptococcus pneumonia. In the present work, author synthesized a library of 3,4-dihydro-1H-benzo[b]azepine-2,5-dione derivatives and evaluated them for their antibacterial potential against a panel of bacterial pathogens. The Structure-activity relationship studies revealed the essential structural features for the promising antibacterial properties against Staphylococcus aureus and Mycobacterium tuberculosis with MIC 4-64μg/mL. In addition, these compounds exhibited favorable selectivity index (SI≥10) in cytotoxicity studies. With the interesting antibacterial properties exhibited and good selectivity index, these compounds have emerged as promising candidates for further development. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)
4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.COA of Formula: C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts