In 2022,Akkoc, Mitat; Bugday, Nesrin; Altin, Serdar; Ozdemir, Ismail; Yasar, Sedat published an article in Catalysis Letters. The title of the article was 《Highly Active Fe3O4@SBA-15@NHC-Pd Catalyst for Suzuki-Miyaura Cross-Coupling Reaction》.Computed Properties of C7H4BrN The author mentioned the following in the article:
A novel Pd-NHC functionalized magnetic Fe3O4@SBA-15@NHC-Pd catalyst was synthesized and used as an efficient heterogeneous catalyst in the Suzuki-Miyaura C-C bond formation reactions. The Fe3O4@SBA-15@NHC-Pd characterized by X-Ray Diffraction (XRD), XPS, Fourier Transform IR (FTIR) spectroscopy, SEM (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray anal. (EDX), Thermogravimetric Anal. (TGA), DTA (DTA). The Inductively Coupled Plasma-Optical emission spectroscopy (ICP-OES) anal. was used to determine the exact amount of Pd (0.33 wt%) in Fe3O4@SBA-15@NHC-Pd. The TEM images of the catalyst showed the existence of palladium nanoparticles immobilized in the catalyst’s structure, while no reducing agent was used. The NHC moieties in the catalyst structure could be stabilize Pd(0) nanoparticles prevents agglomeration. The magnetic catalyst was effectively used in the Suzuki-Miyaura cross-coupling reaction of substituted phenylboronic acid derivatives with (hetero)aryl bromides in the presence of a potassium carbonate at room temperature in aqueous media and magnetic catalyst could be simply extracted from the reaction mixture by an external magnet. Different aryl bromides were converted to coupled-products Ar1Ar2 [Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; Ar2 = Ph, 2-MeC6H4, 1-naphthyl, etc.] in excellent yields with spectacular TOFs values (up to 1,960,339 h-1); in the presence of 1 mg of Fe3O4@SBA-15@NHC-Pd catalyst (contains 3.1 x 10-6 mol% Pd) at room temperature in aqueous media. After reusability experiments, it was found that this catalyst was effectively used up to ten times in the reaction with almost consistent catalytic efficiency. A decrease in the activity of the 10th reused catalyst was found as 9%. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Computed Properties of C7H4BrN)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Computed Properties of C7H4BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts