Yu, Shuling; Lv, Ningning; Liu, Zhanxiang; Zhang, Yuhong published the artcile< Cu(II)-Mediated C-C/C-O Bond Formation via C-H/C-C Bond Cleavage: Access to Benzofurans Using Amide as a Traceless Directing Group>, SDS of cas: 21667-62-9 , the main research area is benzofuran preparation; benzamide benzoylacetonitrile heterocyclization copper catalyst.
A copper-mediated synthesis of 2,3-disubstituted benzofurans I (R1 = H, 5-F, 3-Cl, 5-NO2, etc.; R2 = 4-MeC6H4, 4-FC6H4, 2-thienyl, etc.) with the assistance of an 8-aminoquinolyl auxiliary is described from readily available benzamides R1C6H4C(O)NHQ (Q=) and benzoylacetonitriles R2C6H4C(O)CH2CN. In this reaction, the C-C bond is successfully constructed via C-H activation, and C-O bond is subsequently formed at the original position of the amide group in a one-pot manner. The amide directing group is detached simultaneously under the reaction conditions through C-C bond cleavage. Surprisingly, the distinct isoquinolinone products II (R3 = H, 6-Me, 6-NO2, 7-CF3; R4 = H, Me) can be achieved by changing the reaction conditions using ammonia as amine source.
Advanced Synthesis & Catalysis published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, SDS of cas: 21667-62-9 .
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts