《Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins》 was published in Future Medicinal Chemistry in 2020. These research results belong to Yao, Chun-Hsu; Hsieh, Tsung-Chih; Song, Jen-Shin; Lee, Jinq-Chyi. Electric Literature of C8H6BrN The article mentions the following:
Cancer is a major health burden and a leading cause of death worldwide. We sought to discover potential anticancer mols. with novel scaffold for further development of more active agents to address the issue. A series of β-carboline-1-one hydantoins were designed according to a conformational restriction strategy, synthesized via a one-pot Knoevenagel condensation-intramol. cyclization, and tested in cytotoxicity assays. The study culminated in the identification of 6b and 6c, both of which were found to potently inhibit breast and lung cancer cell lines. Of particular interest was 6c, which was 83 times more potent an inhibitor than 5-fluorouracil in inhibiting MCF-7. This work establishes β-carboline-1-one hydantoin as a promising scaffold in the investigation of anticancer agents. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)
4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts