In 2020,Organic Chemistry Frontiers included an article by Xiao, Qiang; Liu, Jin; Nie, Jia-Hui; Kong, Ling-Bin; Lin, Jun; Yan, Sheng-Jiao. Application of 50743-32-3. The article was titled 《Silver-catalyzed cascade reactions of 3-cyanochromone with 1,1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines》. The information in the text is summarized as follows:
A novel protocol for the construction of highly functionalized 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines I [R = H, Me, Cl, Br, i-Pr; R1 = Me, Ph, 4-ClC6H4(CH2)2, etc.] (PCPMDs) from 3-cyanochromones with 1,1-enediamines via an unprecedented cascade reaction was developed by simply refluxing under the catalysis of silver carbonate. As a result, a series of 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines I was obtained through a novel cascade reaction involving an amazing electrocyclization mechanism of a cyano group with α,β-unsaturated nitriles. This reaction formation of compounds I was accompanied by the formation of four bonds and the cleavage of one bond in one step. This protocol could be used for the synthesis of various pyridin-3-yl-substituted complex pyrimidine derivatives, and it was suitable for combinatorial and parallel synthesis of PCPMD drugs or natural-like products. In the experiment, the researchers used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application of 50743-32-3)
6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application of 50743-32-3 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts