Ujjinamatada, Ravi K.; Agasimundin, Yankanagouda S.; Zhang, Peng; Hosmane, Ramachandra S.; Schuessler, Roman; Borowski, Peter; Kalicharran, Kishna; Fattom, Ali published the artcile< A Novel Imidazole Nucleoside Containing a Diamino-dihydro-S-triazine as a Substituent: Inhibitory Activity Against the West Nile Virus NTPase/Helicase>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is condensation ring enlargement guanosine imidazodiazepine guanidine deoxyerythropentofuranosyl ethoxycarbonylimidazolecarbaldehyde; helicase West Nile virus antiviral imidazole nucleoside aminodihydrotriazine synthesis; West Nile virus NTPase antiviral imidazole nucleoside aminodihydrotriazine synthesis.
The attempted synthesis of a ring-expanded guanosine containing the imidazo[4,5-e][1,3]diazepine ring system by condensation of 1-(2′-deoxy-β-D-erythropentofuranosyl)-4-ethoxycarbonylimidazole-5-carbaldehyde with guanidine resulted in the formation of an unexpected product, 1-(2′-deoxy-β-D-erythropentofuranosyl)-5-(2,4-diamino-3,6-dihydro-1,3,5-triazin-6-yl)imidazole-4-carboxamide (I). The structure as well as the pathway of formation of I was corroborated by isolation of the intermediate, followed by its conversion to the product. Nucleoside I showed promising in vitro anti-helicase activity against the West Nile virus NTPase/helicase with an IC50 of 3-10 μg/mL.
Nucleosides, Nucleotides & Nucleic Acids published new progress about Antiviral agents. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts