Tian, Shi-Kai; Hong, Ran; Deng, Li published the artcile< Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base>, SDS of cas: 6136-93-2, the main research area is ketone dialkoxy catalytic asym cyanosilylation chiral Lewis base; cyanohydrin silylated asym synthesis; cinchona alkaloid chiral catalyst enantioselective cyanosilylation dialkoxy ketone.
A highly enantioselective cyanosilylation of α,α-dialkoxy ketones R1COCH(OR2) (R1 = Me, Me2CH, n-Bu, Ph, 4-MeOC6H4, PhCH2, PhCH:CH, PhCC, etc.; R2 = Et, n-Pr) with trimethylsilyl cyanide catalyzed by modified cinchona alkaloids was developed. This reaction is the first highly enantioselective cyanosilylation of ketones catalyzed by an organic chiral Lewis base and, combined with the versatility of the acetal functionality, provides a broadly useful synthetic method for chiral building blocks bearing quaternary stereocenters. Acetal ketones, readily accessible but previously unexplored in asym. synthesis, demonstrate unusual reactivity and selectivity toward the nucleophilic cyanosilylation, thereby suggesting that they may be interesting substrates for other catalytic enantioselective reactions.
Journal of the American Chemical Society published new progress about Addition reaction, stereoselective (cyanosilylation). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts